I have been working on upgrading the caching contrib modules to Drupal 6 and started to notice some patterns and duplicated code, which led me to think Drupal's approach to caching in general. We currently have a fairly limited API for caching, but we have a magic bullet that helps us overcome some of these weaknesses: the cache.inc override system. Anyone who has spent time on large production sites knows that one of the easiest ways to see better performance on your Drupal system is to use one of the existing cache mechanisms that I spoke about at Drupalcon Boston.